After administering three doses of Atropine for a suspected Beta-Blocker overdose, what should be given next?

In cases of suspected Beta-Blocker overdose, Atropine is often administered to counteract bradycardia. However, if the bradycardia persists despite multiple doses of Atropine, Glucagon is the recommended next step. Glucagon works by increasing heart rate and contractility, thus addressing the cardiovascular effects associated with Beta-Blocker toxicity. It promotes the release of stored glucose and helps overcome the Beta-Blocker’s effects on the heart by enhancing cardiac output.

This understanding is crucial because while other treatments like Naloxone, Dextrose, and Calcium Gluconate have their specific uses in emergency scenarios, they do not directly mitigate the effects of a Beta-Blocker overdose. Glucagon is particularly effective in this context due to its mechanism of action, making it the appropriate choice after administering Atropine when there is insufficient response to restore normal heart rate and function.