When delivering a drug via endotracheal tube, how many times the IV dose must be administered?

When delivering a drug via an endotracheal tube, it is generally recommended to administer the drug at a dose of 2 to 2.5 times the intravenous (IV) dosage. This adjustment is necessary because the absorption of medication through the endotracheal route is less reliable compared to intravenous administration. The increased dosage compensates for the variability in drug delivery and ensures that an adequate therapeutic effect is achieved quickly, especially in emergency situations where rapid intervention is critical.

This dosing protocol is particularly important for certain medications due to differences in their bioavailability when administered via this route. Understanding the pharmacokinetics of the drug and the appropriate route of administration is essential for effective treatment.